Big Books & Bold Ideas with Kerri Miller

New research into Alzheimer’s disease and dementia 

Alzheimer's damage
The scan on the left shows a healthy brain. The one on the right shows the damage caused by Alzheimer's disease.
Image courtesy of the National Institute on Aging

The number of people with Alzheimer’s disease is surging as baby boomers reach the age when the risk of dementia soars. Drugs to slow memory decline have proved elusive, but researchers are learning more every year about what influences cognitive problems and possible ways to prevent them. 

Researchers recently found dementia is more common in the Southeast and Gulf Coast states, including Florida and Texas, compared with Western states, such as Colorado and Arizona. Poverty, lower education and other social conditions may contribute to the variation. 

Another study published this year by researchers at the University of Wisconsin School of Medicine and Public Health found that people who lived in the poorest neighborhoods at the time they died were twice as likely to have brain changes typical of Alzheimer’s disease as people who lived in the wealthiest neighborhoods. 

A commission formed by British health journal The Lancet reported this summer that managing 12 specific risk factors, including obesity, high blood pressure and air pollution, could prevent or delay about 40 percent of dementia cases worldwide. And other research  discovered that poor sleep can predict cognitive problems and that deep sleep may help brains stay healthy.

Meanwhile, blood tests that diagnose Alzheimer’s disease are on the horizon. They measure changes in specific proteins that until now could only be detected through expensive brain scans or a spinal fluid sample taken from the lower back. 

Thursday, MPR News host Kerri Miller talked with a clinical neurologist and an epidemiologist about the broad frontier of Alzheimer’s research. 


  • Dr. David Knopman is a clinical neurologist and researcher at Mayo Clinic and scientific integrity adviser for the journal Neurology. 

  • Megan Zuelsdorff is an assistant professor in the School of Nursing at the University of Wisconsin-Madison and an investigator with the Wisconsin Alzheimer's Disease Research Center.

Correction (Dec. 3, 2020): A previous version of this story listed an incorrect title for Knopman’s role at the journal Neurology. The story has been updated.

To listen to the full conversation use the audio player above.

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