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Prescription drug prices continue to climb, putting the pinch on consumers. Some older Americans appear to be seeking an alternative to mainstream medicines that has become easier to get legally in many parts of the country.

 Wednesday found that states that legalized medical marijuana — which is sometimes recommended for symptoms like chronic pain, anxiety or depression — saw declines in the number of Medicare prescriptions for drugs used to treat those conditions and a dip in spending by Medicare Part D, which covers the cost on prescription medications.


Because the prescriptions for drugs like opioid painkillers and antidepressants — and associated Medicare spending on those drugs — fell in states where marijuana could feasibly be used as a replacement, the researchers said it appears likely legalization led to a drop in prescriptions. That point, they said, is strengthened because prescriptions didn't drop for medicines such as blood-thinners, for which marijuana isn't an alternative.

 examined data from Medicare Part D from 2010 to 2013. It is the first study to examine whether legalization of marijuana changes doctors' clinical practice and whether it could curb public health costs.
The findings add context to the debate as more lawmakers express interest in medical marijuana. This year, 

 passed laws allowing the drug for therapeutic purposes, making it legal in 

. The approach could also come to a vote in 

 this November. A federal agency is considering reclassifying medical marijuana under national drug policy to make it more readily available.


Medical marijuana saved Medicare about $165 million in 2013, the researchers concluded. They estimated that, if medical marijuana were available nationwide, Medicare Part D spending would have declined in the same year by about $470 million. That's about half a percent of the program's total expenditures.


That is an admittedly small proportion of the multibillion-dollar program. But the figure is nothing to sneeze at, said 

, a professor of public policy at the University of Georgia and one of the study's authors.


"We wouldn't say that saving money is the reason to adopt this. But it should be part of the discussion," he added. "We think it's pretty good indirect evidence that people are using this as medication."

The researchers found that in states with medical marijuana laws on the books, the number of prescriptions dropped for drugs to treat anxiety, depression, nausea, pain, psychosis, seizures, sleep disorders and spasticity. Those are all conditions for which marijuana is sometimes recommended.

The study's authors are separately investigating the effect medical marijuana could have on prescriptions covered by Medicaid, the federal-state health insurance program for low-income people. Though this research is still being finalized, they found a greater drop in prescription drug payments there, Bradford said.


If the trend bears out, it could have other public health ramifications. In states that legalized medical uses of marijuana, painkiller prescriptions dropped — on average, the study found, by about 1,800 daily doses filled each year per doctor. That tracks with 

Marijuana is unlike other drugs, such as opioids, overdoses of which can be fatal, said Deepak D'Souza, a professor of psychiatry at Yale School of Medicine, who has researched marijuana. "That doesn't happen with marijuana," he added. "But there are whole other side effects and safety issues we need to be aware of."

Study author Bradford agreed: "Just because it's not as dangerous as some other dangerous things, it doesn't mean you want to necessarily promote it. There's a lot of unanswered questions."


Because the federal government classifies marijuana as a 

, doctors can't technically prescribe it. In states that have legalized medical marijuana, they can only write patients a note sending them to a dispensary.
Insurance plans don't cover it, so patients using marijuana pay out of pocket. Prices vary based on location, but a patient's recommended regimen can cost as much as 

 changing that classification — a decision is expected 

. If the DEA made marijuana a Schedule II drug, the move would put it in the company of drugs such as morphine and oxycodone, making it easier for doctors to prescribe and more likely that insurance would cover it.


To some, the idea that medical marijuana triggers cost savings is hollow. Instead, they say it is cost shifting. "Even if Medicare may be saving money, medical marijuana doesn't come for free," D'Souza said. "I have some trouble with the idea that this is a source of savings."

Still, Bradford maintains that if medical marijuana became a regular part of patient care nationally, the cost curve would bend because marijuana is cheaper than other drugs.

Lester Grinspoon, an associate professor emeritus of psychiatry at Harvard Medical School, who has written two books on the subject, echoed that possibility. Unlike with many drugs, he argued, "There's a limit to how high a price cannabis can be sold at as a medicine." He isn't associated with the study.

And, in the midst of the debate about its economics, medical marijuana still sometimes triggers questions within the practice of medicine.

"As physicians, we are used to prescribing a dose. We don't have good information about what is a good dose for the treatment for, say, pain," D'Souza said. "Do you say, 'Take two hits and call me in the morning?' I have no idea."

Kaiser Health News is a national health policy news service that is part of the nonpartisan Henry J. Kaiser Family Foundation.

Health

Shefali Luthra

Author

Some older Americans appear to be seeking an alternative to mainstream medicines that has become easier to get legally in many parts of the country.

After medical marijuana legalized, Medicare prescriptions drop for many drugs

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