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When teaching hospitals put pharmaceutical sales representatives on a shorter leash, their doctors tended to order fewer promoted brand-name drugs and used more generic versions instead, a 

, the journal of the American Medical Association, shows.
The results were significant compared to doctors who worked at hospitals that did not limit sales reps from freely walking their halls or providing meals or gifts, according to research by 

, an assistant professor of strategy at the University of California, Los Angeles Anderson School of Management, and colleagues.
This issue of 

 is devoted to conflicts of interest in medicine and includes a 

 on what ProPublica has learned by publishing 

, a tool that lets users look up their physicians' payments from drug and medical device companies.



Conflicts of interest in medicine have been ubiquitous for years, but a string of lawsuits, coupled with a crackdown by academic medical centers and public disclosure of industry payments, have brought renewed focus on how these relationships affect prescribing.


For the past 6 1/2 years, ProPublica has tracked payments to doctors. We've found that 

some practitioners earn hundreds of thousands of dollars

 or more each year working with drug and device companies. We've reported how the drugs most aggressively promoted to doctors 

 or even big medical breakthroughs. And last year we found an 

 and higher rates of brand-name prescribing, on average.


The teaching hospital study focused on 19 centers in five states that restricted visits by drug reps in one or more ways: limiting access, limiting gifts or punishing those who broke the rules. Larkin's team compared prescriptions by 2,126 doctors at those hospitals with 24,593 peers with similar characteristics who were not subject to the marketing limits. It examined more than 16 million prescriptions in total, using data from CVS Caremark, a large pharmacy benefit manager.

The researchers found significant changes in six of the eight drug classes studied and at nine of the 19 hospitals reviewed. The policies were put in place at different times from 2006 to 2011, but changes in prescribing started immediately and lasted for 12 to 36 months afterward.

Having a policy governing pharmaceutical marketing, known as "detailing," was associated with a 1.67 percentage point decrease in market share for the average promoted drug. Before the policies, the average promoted drug had a market share of 19.3 percent. Those with tougher policies, including an enforcement component, appeared to have more significant results.

"These weren't terribly onerous restrictions, yet at the same time, they changed prescribing in a way that has really significant cost implications," Larkin said.


Among the centers that did not have statistically significant changes was Stanford University, one of the earliest adopters of restrictive policies. In 2010, ProPublica 

 how Stanford was not enforcing its rules limiting the relationships between doctors and drug companies. It has tightened its oversight since. Stanford doctors prescribed fewer promoted drugs but not enough for the result to be significant.


Larkin says he was surprised that the policies at some teaching hospitals didn't have as much impact as the researchers expected. "You can't just put in a policy," he says. "You have to think about it carefully, think about the efforts that really matter and involve the [medical] community."

The study has several limitations. First, it did not find that the policies caused the change in prescribing, only that there was an association between the two. Also, the study was observational, meaning that doctors were not randomly assigned to hospitals with and without policies. And the study took policies at their word, not looking at their implementation or follow through.

's editor in chief, said the study helps to crystalize the need to limit pharmaceutical company marketing in teaching hospitals "as a way of ensuring that there's no influence, no inappropriate influence over prescribing."


Bauchner says he isn't bothered that the researchers found significant results in fewer than half of the teaching hospitals studied. "Nothing is ever 100 percent effective," he says. "To me that's no different than a clinical trial. Not everyone benefits."

 that accompanies the research suggests that alternative approaches to educating doctors about drugs besides relying on drug company promotion need to be tested. "It has never been more important for physicians to come together to consider these alternatives, generate evidence about their effectiveness, and move the health care system toward solutions that lower costs for patients and minimize" conflicts of interest, write Colette DeJong and Dr. R. Adams Dudley of the University of California, San Francisco.  Copyright 2019 ProPublica. To see more, visit 

Health

Charles Ornstein

Author

Doctors were more likely to choose generic drugs over pricier brand names when teaching hospitals limited access by pharmaceutical sales representatives, a study finds.

Doctors prescribe more generics when drug reps are kept at bay

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