Southern Minnesota authorities have issued an arrest warrant for Izetta Cooley, who police say took her five children without permission.
Cooley, 39, is court-ordered not to have contact with her children.
But on Saturday night, police say, she took at least three of them from the home where they were staying in Rose Creek, a small town in southeastern Minnesota.
The five children are Mateo, 10; Mollycia, 11; Mojo, 13; Morgan, 16; and Marco, 17.
The Bureau of Criminal Apprehension has posted pictures of the children and their mother on its Facebook page.
The BCA says the children might not be together, and could be in Minnesota or the Dakotas.
Police say Cooley is likely driving a black 2007 Suzuki XL7 with a Minnesota license plate.
Cooley's husband, 44-year-old Miguel Cooley of Moorhead, Minn., is accused of fatally shooting 20-year-old Gabriel Perez outside a McDonald's restaurant in Fargo, N.D., on Sept. 23. Miguel Cooley was later arrested in southeastern Minnesota.
The BCA is asking anyone with information to call 911 or the Mower County Sheriff's Office at 507-437-9400.