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While millions wait for a lifesaving shot, the U.S. death toll from the coronavirus continues to soar upward with horrifying speed. On Tuesday, the last full day of Donald Trump's presidency,

the official death count reached 400,000 — a once-unthinkable number. More than 100,000 Americans have perished in the pandemic in just the past five weeks. 

In the U.S., someone now dies from COVID-19 every 26 seconds. And the disease is now 

 each week than any other condition, ahead of heart disease and cancer, according to the 

Institute for Health Metrics and Evaluation

"It didn't have to be like this, and it shouldn't still be like this," says Kristin Urquiza, who began communicating with other grieving family members after her father, Mark, died from COVID-19 on June 30 as the virus was sweeping through Phoenix. 

Urquiza described it as "watching a slow-moving hurricane" tear apart her childhood neighborhood, where many people have no choice but to keep going to work and risking their health.

"I talk to dozens of strangers a day who are going through what I did in June, but the magnitude and the haunting similarities between our stories six months later is really hard," Urquiza says. 

, which is calling for a faster government response and a national memorial for pandemic victims. 

Given its relatively large population, the U.S. death 

from COVID-19 remains lower than that of many other countries. But the cumulative death toll of 400,000 now exceeds any other country's overall mortality — close to 

 what Brazil has recorded, and four times the death count in the United Kingdom.

It's very hard to wrap your mind around a number that is so large, particularly when we've had 10 months of large numbers assaulting our senses and really, really horrific images coming out of our hospitals and our morgues," says 

, chair of epidemiology at the University of California, San Francisco. 

Scientists had long anticipated that wintertime could plunge the country into the deadliest months yet, but even Bibbins-Domingo wasn't ready for the sheer pace of deaths, or the scale of the accumulated losses. The mortality burden has fallen heavily on her state of California, a place that was averaging fewer than 100 deaths a day for long stretches of the pandemic but is now recording more than 

She says California may have followed the science with its handling of the pandemic and yet the devastation unfolding in places such as Los Angeles reveals just how fragile any community can be. 

"It's important to understand virology. It's important to understand epidemiology. But ultimately, what we've learned is that human behavior and psychology is a major force in this pandemic," she says. 

The U.S is now averaging more than 3,300 deaths a day — well above the most devastating days of the early spring surge when the daily average deaths hovered around 2,000.

 "At this point, looking at the numbers, for me the question is: Is there any way we can avoid half a million deaths before the end of February?" says 

 dean of the Brown University School of Public Health. 

"I think of how much suffering as a nation we seem to be willing to accept that we have this number of people getting infected and dying every day."

How did the U.S. go from 300,000 deaths to 400,000?

The path to 400,000 deaths was painfully familiar, with patterns of sickness and death repeating themselves from earlier in the pandemic. 

A shocking number of people in nursing homes and assisted living facilities 

 of those residents died just in the first week of January. 

Deaths linked to long-term care now account for more than a third of all COVID-19 deaths in the U.S. since the beginning of the pandemic. In a 

, long-term care contributed to half of the total deaths. 

Certain parts of the country have a disproportionately high death rate. Alabama and Arizona, in particular, have experienced some of the highest 

, given their populations. The virus continues to kill Black and Indigenous Americans at much 

, the chance of dying from COVID-19 remains much higher than in the urban centers. 

People over 65 make up the overwhelming majority of deaths, but Jha says more young people are dying than earlier in the pandemic simply because the virus is so widespread. 

In this newest and grimmest chapter of the pandemic, the virus has preyed upon a public weary of restrictions and rules, and eager to mix socially with family and friends over the holiday season. 

 at Johns Hopkins Hospital is now witnessing the tragic consequences in his daily rounds. 

"My heart breaks because we could have prevented this," says Galiatsatos, an assistant professor of medicine who cares for COVID-19 patients in the intensive care unit.

"A lot of what we saw during the holiday travel was the inability to reach our loved ones or family members — not like a public service announcement, but one-on-one talking to them [about the exposure risks]. ...  I really felt like we failed

Galiatsatos still recalls a grandmother who was transported six hours from her home to his hospital — because there were no beds anywhere closer. 

On the phone, he heard her family's shock at her sudden passing. 

"They said: 'But she was so healthy, she cooked us all Thanksgiving dinner and we had all the family over,' " he says. "They were saying it with sincerity, but that's probably where she got it."

Vaccine rollout has yet to catch up with an accelerating mortality rate 

The enormous loss of life this winter has happened paradoxically at a time that many hope marks the start of the final chapter of the pandemic. 

A quarter of all COVID-19 deaths have happened during the five-week period since the Food and Drug Administration authorized the first vaccine on Dec. 14.

"The trickle of vaccine is so tragically scant —what we need is more of a river of it," says 

 who directs the University of Michigan's 

Markel, who has written about the 1918-19 flu pandemic, says it's estimated that killed upward of 700,000 Americans. 

Regarding the current coronavirus pandemic, Markel says, "I hope we're not talking ... 600,000 or more." 

 rollout followed as states, counties and even individual hospitals struggled to store the first refrigerated shipments of vaccine and arrange for busy health care workers to get it. So far, about

people have gotten at least one dose of the vaccine, placing America ahead of many other countries, but behind the optimistic promises made in the early days of the rollout. 

Given the current pace of vaccination, experts warn Americans cannot depend solely on the vaccine to prevent a crushing number of additional deaths in the coming months. 

Bibbins-Domingo of the University of California, San Francisco worries the relief of knowing that a vaccine will eventually be widely available — the so-called light at the end of the tunnel — may lull millions of more Americans into a false sense of safety.

"This tunnel is actually a very long tunnel, and the next few months, as the last few months have been, are going to be very dark times," she says. 

The emergence of new, more contagious variants of SARS-CoV-2 only complicates the picture and makes it all the more imperative that Americans spend the coming months doubling down on the same tactics — face masks and physical distancing — that have kept many people safe from the virus so far. 

But Jha says the country now faces a different task compared with the fall when "big behavioral changes and large economic costs" were required to prevent deaths. 

"Right now what is required is getting people vaccinated with vaccines we already have," he says. "The fact that's going super slow still is incredibly frustrating."

It is this polarity — the advent of a lifesaving vaccine and hospitals filled with more dying patients than ever before — that makes this particular moment in the pandemic so confounding. 

"I can't help but feel this immense somberness," Urquiza says. "I know that a vaccine isn't going to make a difference for the people that are in the hospital right now, or who will be in the hospital next week, or even next month." 

This story was produced in partnership with 

Health

COVID-19

Will Stone

Author

Although vaccination has begun, this winter has been the deadliest season of the pandemic. The U.S. death toll jumped from 300,000 to 400,000 in just five weeks.

As death rate accelerates, U.S. records 400,000 lives lost to the coronavirus

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