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Wall Street pointed modestly higher ahead of the Federal Reserve's last policy meeting of 2022, where it's expected the central bank will raise its main lending rate by another half-point. Futures for the S&P 500 rose about 0.3 percent early Monday and futures for the Dow inched up about 0.2 percent. Markets were also waiting for an update on U.S. consumer prices Tuesday, the last important piece of data about inflation before the Fed opens its two-day meeting. Shares in Horizon Therapeutics jumped more than 14 percent in premarket after Amgen announced it would acquire the biopharmaceutical company for about $26.4 billion.

Wall Street futures pointed modestly higher Monday ahead of the Federal Reserve's last policy meeting of 2022, where it's expected the central bank will raise its main lending rate by another half-point.

Futures for the S&P 500 rose about 0.3 percent and the Dow Jones Industrial Average inched up about 0.2 percent.

Markets were also waiting for an update on U.S. consumer prices Tuesday, the last important piece of data about inflation before the Fed opens its two-day meeting this week. Economists expect the consumer price index to show inflation slowed to 7.3 percent last month from 7.7 percent in October.

Meetings of major central banks including the Fed mean "there is potential for a whole load of volatility in markets; especially given the palpable tensions between inflation risks and fears of policy-induced recession," analysts at Mizuho Bank said in a commentary.

Asian markets closed lower Monday amid signs of a surge in coronavirus infections in China that suggested progress may be uneven as it rolls back its "zero-COVID" pandemic restrictions.

China was setting up more intensive care facilities and trying to strengthen hospitals as it rolls back anti-virus controls that confined millions of people to their homes, crushed economic growth and set off protests.

The precautions come as the number of cases appeared to be rising, though a sharp reduction in the number of tests being administered makes measuring any changes difficult.

President Xi Jinping's government is officially committed to stopping virus transmission, the last major country to try. But the latest moves suggest the ruling Communist Party has decided to tolerate more cases without quarantines or shutting down travel or businesses as it winds down its "zero-COVID" strategy.

Hong Kong's Hang Seng sank 2.1 percent to 19,475.16 and the Shanghai Composite index shed 0.9 percent to 3,179.04.

Shares in e-commerce and other tech-related companies that thrived during the days of lockdowns as home deliveries soared were sharply lower. Meituan fell 7 percent and Baidu also dropped 7 percent. E-commerce giant Alibaba sank 3.8 percent and JD.com lost 2.9 percent.

Tokyo's Nikkei 225 index gave up 0.2 percent to 27,842.33 after a survey of Japanese manufacturers released Monday showed a sharp deterioration in their outlook, with recession a growing possibility in the U.S. and other major markets. The business survey index fell to minus 3.6% in October-December from 1.7% in the previous quarter as manufacturers grappled with high prices for energy and other raw materials.

The Kospi in Seoul lost 0.7 percent to 2,373.02 and Australia's S&P/ASX 200 declined 0.5 percent to 7,180.80.

Markets in Thailand were closed for a holiday.

In Europe at midday, Germany's DAX and the CAC 40 in Paris each shed 0.4 percent and Britain's FTSE 100 gave up 0.3 percent.

Shares in Horizon Therapeutics jumped more than 14 percent in premarket trading Monday after Amgen announced it would acquire the biopharmaceutical company for about $26.4 billion.

Amgen said Monday that the Horizon transaction will give it access to a complementary portfolio of medicines from Horizon that address the needs of patients suffering from rare diseases. Shareholders of Horizon, a company which focuses on treatments for rare autoimmune diseases, will get $116.50 for each share they own in the deal.

U.S. markets fell last week with anxious investors focusing on a government report showing that prices paid at the wholesale level were 7.4 percent higher in November than a year earlier. That's a slowdown from October's wholesale inflation rate of 8.1 percent, but it was still slightly worse than economists expected.

The Fed has been battling inflation by aggressively raising interest rates to raise the cost of borrowing and slow economic activity. The central bank has already hiked its key overnight rate to a range of 3.75 percent to 4 percent, up from basically zero as recently as March.

Stocks have been battered this year by the withdrawal of pandemic stimulus and rising rates, which make other investments more attractive. They've recovered some of their losses recently, as inflation has slowed since hitting a peak in the summer. But price gains remain high, raising the risk the Federal Reserve will have to keep hiking interest rates sharply to get it fully under control.

In other trading Monday, U.S. benchmark crude oil lost 30 cents to $70.22 per barrel in electronic trading on the New York Mercantile Exchange.

Brent crude, the pricing basis for international trading, dropped 55 cents to $75.57 per barrel.

The U.S. dollar rose to 136.93 Japanese yen from 136.60 yen. The euro rose to $1.0564 from $1.0537.

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Wall Street pointed modestly higher ahead of the Federal Reserve’s last policy meeting of 2022, where it’s expected the central bank will raise its main lending rate by another half-point. 

U.S. futures rise ahead of last Fed policy meeting of 2022

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