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As the U.S. heads into a third pandemic winter, the first hints are emerging that another possible surge of COVID-19 infections could be on its way.

So far, no national surge has started yet. The number of people getting infected, hospitalized and dying from COVID in the U.S. has been 

But as the weather cools and people start spending more time inside, where the virus spreads more easily, the risks of a resurgence increase.

The first hint of what could be in store is what's happening in Europe. Infections 

have been rising in many European countries, including the U.K., France, 

"In the past, what's happened in Europe often has been a harbinger for what's about to happen in the United States," says 

 director of the Center for Infectious Disease Research and Policy at the University of Minnesota. "So I think the bottom line message for us in this country is: We have to be prepared for what they are beginning to see in Europe."

are projecting that COVID infections will 

continue to recede at least through the end of the year

. But researchers stress there are many uncertainties that could change that, such as as whether more infectious variants start to spread fast in the U.S.

 that have emerged recently that appear to be even better at dodging immunity.

"We look around the world and see countries such as Germany and France are seeing increases as we speak," says 

 at the University of Texas at Austin. "That gives me pause. It adds uncertainty about what we can expect in the coming weeks and the coming months."

However, it's not certain the U.S. experience will echo Europe's, says Justin Lessler, an epidemiologist at the University of North Carolina who helps run the 

That's because it's not clear whether Europe's rising cases are related to people's greater susceptibility to new subvariants they've not yet been exposed to. In addition, different countries have different levels of immunity.

"If it is mostly just behavioral changes and climate, we might be able to avoid similar upticks if there is broad uptake of the bivalent vaccine," Lessler says. "If it is immune escape across several variants with convergent evolution, the outlook for the U.S. may be more concerning."

In fact, some researchers say the U.S. is already starting to see early signs of that. For example, the

 levels of virus being detected in wastewater is up in some parts of the country

, such in Pennsylvania, Connecticut, Vermont and other parts of Northeast. That could an early-warning sign of what's coming, though overall the virus is declining nationally.

"It's really too early to say something big is happening, but it's something that we're keeping an eye on," says 

 national wastewater surveillance program lead at the Centers for Disease Control and Prevention.

But infections and even hospitalizations have started rising in some of the same parts of New England, as well as some other northern areas, such as the Pacific Northwest, according to Dr. 

, the director of the PolicyLab at Children's Hospital of Philadelphia, which tracks the pandemic.

"We're seeing the northern rim of the country beginning to show some evidence of increasing transmission," Rubin says. "The winter resurgence is beginning."

Assuming no dramatically different new variant emerges, it appears highly unlikely this year's surge would get as severe as the last two years in terms of severe disease and deaths.

"We have a lot more immunity in the population than we did last winter," says 

, who runs the Pandemic Center at the Brown University School of Public Health.

"Not only have people gotten vaccinated, but a lot of people have now gotten this virus. In fact, some people have gotten it multiple times. And that does build up [immunity] in the population and reduce overall over risk of severe illness," Nuzzo says.

Another crucial variable that could affect how the impact of a rise of infections is how many people get one of the 

But booster uptake in the U.S. was already sluggish. "Nearly 50% of people who are eligible for a booster have not gotten one," says 

, an associate professor of epidemiology at the Harvard T.H. Chan School of Public Health. "It's wild. It's really crazy."

And the demand for the newest boosters is pretty lethargic so far. 

Less than 8 million people have gotten one of the new boosters

 since they became available over the Labor Day weekend even though more than 200 million are eligible.

Given the likelihood of a surge, it's critical people up to date on vaccines, says Nuzzo. "The most important thing that we could do is to take off the table that this virus can cause severe illness and death," she says.


"There are a lot of people who could really benefit from getting boosted but have not done so."


Health

Social Issues

COVID-19

Rob Stein

Author

Here we go again. The virus is starting to surge in many European countries and there are early signs a wave may be starting in the U.S. too.

Early signs a new U.S. COVID surge could be on its way

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