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More than 200,000 people are testing positive for COVID-19 

. Until this week, a positive test meant you should stay home for 10 days to avoid infecting others. Now, those who don't have symptoms after five days can go back to their regular activities as long as they wear a mask, according to 

updated guidance from the Centers for Disease Control and Prevention

The change in guidance released Monday was "motivated by science demonstrating that the majority of SARS-CoV-2 transmission occurs early in the course of illness," according to the CDC.

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CDC director Dr. Rochelle Walensky says the change was also motivated by economic and societal concerns. "With a really large anticipated number of cases [from omicron], we also want to make sure we can keep the critical functions of society open and operating," she 

. "We can't take science in a vacuum. We have to put science in the context of how it can be implemented in a functional society."

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Public health experts say a shorter isolation period may be reasonable at this point in the pandemic, but they say the agency's new guidance is problematic because it relies on people's self-judgment to assess their transmission risk —  and could lead to more spread and more COVID-19 cases if people aren't careful. 

University of Minnesota infectious disease expert Michael Osterholm says the new guidance is imperfect but necessary and that a perfect policy would require a negative test before resuming regular routines — and that everyone has a proper mask.

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But Osterholm says there's not enough reliable testing capacity to make that work. 

"How do we do the best we can to limit any kind of transmission of the virus from one person to another, but at the same time, assure ourselves that hospital beds will have somebody standing by them at least once every eight hours?” said Osterholm.

Minnesota's nurses union is raising concerns about the new federal guidance. Minnesota Nurses Association president Mary Turner says the guidance risks further straining hospital capacity. 

"I just don't have a good feeling about it — in the sense of inundating us with more patients who we have no room for,” Turner said.

Turner is also concerned that the guidance puts the responsibility of masking on people who may not have adequate personal protective equipment. 

 happen in the first couple of days after the onset of symptoms ... but the data shows that about 20 to 40 percent of people are still going to be able to transmit COVID after five days," says 

, an infectious disease specialist at UChicago Medicine. "Is that person [leaving isolation after five days] really safe to carpool with or have close contact with or have them take care of your unvaccinated kids?"

Mask adherence is essential to this policy being effective, Landon says. The guidance assumes that people will wear a mask for five days after coming out of isolation if infected, and for 10 days if they were exposed to a positive case. But mask compliance in the U.S. is generally low. 

"Many people will wear their masks on their chins or below their noses, which is useless for preventing transmission," says 

, an infectious disease specialist and epidemiologist at the NYU School of Medicine and Bellevue Hospital, who previously served as a COVID-19 adviser to President Joe Biden.

 of public health experts who think the guidance relies too heavily on the honor system.  

"We should really be using objective concrete measures to decide whether somebody needs to continue being in isolation, such as rapid antigen testing," Gounder says. 

Others were more blunt: "CDC's new guidance to drop isolation of positives to five days without a negative test is reckless," tweeted 

. "I absolutely don't want to sit next to someone who turned [positive] five days ago and hasn't tested [negative]." 

The guidance doesn't require a negative test to leave isolation or quarantine — it says to test "if possible" after five days if you were exposed. However, this comes at a time when COVID-19 tests are in short supply. People are queueing up at malls and around city blocks, sometimes for hours, to get tested. Rapid tests are 

Gounder sees the absence of a testing requirement in these updated CDC guidelines as an "example of scarcity determining policy." The tests could work, she says — but there are just not enough tests readily available. 

The CDC's Walensky defended the new COVID-19 recommendations in an interview with 

. "We're trusting [people] to get the test to begin with. We're trusting them to stay home and to isolate for those first five days. We're trusting them to protect one another and wear a mask in those last five days, and we're trusting them to include their symptoms as part of that calculus," she said. "I think we, as a society, need to trust people to follow all of the components of this guidance."

Despite the administration's emphasis on COVID-19 vaccines and boosters, the guidelines make little distinction between the vaccinated and unvaccinated, "who are clearly facing very different pandemics at the moment," says 

"Vaccinated people are much less likely to get infected and less likely to be infectious for a long period of time," he says. With that in mind, he thinks the CDC should have tailored the guidelines to distinguish between those who are protected by vaccines and those who are not. 

Still, some experts say the new recommendations are a useful step forward. "I think they're prudent," says Dr. Monica Gandhi, an infectious disease specialist at the University of California, San Francisco. "I think they're based on data from the omicron variant from South Africa, and they make sense." The guidance follows a similar policy update in 

., which shortened its isolation requirements during the omicron surge, though the U.K.'s policy has a testing requirement for ending self-isolation.

The CDC's guidance updates come at the end of a long first month with the omicron variant. State and industry leaders have pushed for a reduced isolation period, blaming the lengthy at-home stay for worker shortages 

, postponed sports games and events and restaurant closures. 

The change in guidance to the public expands on 

 periods for health care workers introduced 

. Where there are staffing shortages, the CDC recommends that infected workers isolate for five days before returning. In crisis times, they say workers should go to work even if they're sick with COVID-19. 

"I don't know a lot of people that feel super comfortable with this decision," says 

, a hospital epidemiologist and assistant professor at George Mason University. On the one hand, health care staff wear high-quality masks at work, making them unlikely to transmit infections to patients. On the other hand, they can't wear masks all the time. 

"They still need to eat. They still need to drink. They need to take breaks." Hospitals will need to think through the risks of the policy when deciding whether to implement it, she says. 

While the new guidance may have room for improvement, ultimately the bigger problem is people who aren't paying attention to public health guidance at all, 

, chief medical executive for the state of Michigan, 

"What I'm more concerned about in places like Michigan are people who are continuing on with their lives as though there is no pandemic," she said. It's the people who are unvaccinated, not testing and not masking that are driving the current surge, she said. 

NPR's Allison Aubrey contributed to this report.

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Cutting the isolation for positive cases to five days could lead to more infections if people don't take masking seriously. Experts including Minnesota infectious disease specialist Michael Osterholm say a testing requirement would have made the policy safer.

New CDC isolation guidelines raise concerns among health experts

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